Vanguards of Paradigm Shift in Radiation Biology: Radiation-Induced Adaptive and Bystander Responses
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چکیده
منابع مشابه
Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses.
The risks of exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to high dose radiation, using a linear no-threshold model (LNT model). However, the validity of using this dose-response model is controversial because evidence accumulated over the past decade has indicated that living organisms, including humans, respond differ...
متن کاملRadiation-induced adaptive responses and bystander effects.
A classical paradigm [correction of paradym] of radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation. However, there has been a recent growth of interest in the indirect actions of radiation including the radiation-induced adaptive response, the bystander effect, low-dose hypersensitivity, and genomic instability, which a...
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Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects. Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent years. RIBE occurs in unexposed cells which are related to adjacent or distant irradiated cells. RIBE contradict with "target theory" which necessitates radiation tr...
متن کاملThe Mechanisms of Radiation-Induced Bystander Effect
The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...
متن کاملLow-dose radiation: thresholds, bystander effects, and adaptive responses.
I onizing radiation fills the universe. Daily ionizing particles and rays collide with molecules in 1% of the 100 trillion cells that make up the average human. These collisions generate clusters of free radicals known as reactive oxygen species that randomly damage cellular constituents including DNA (1). Certain types of ionizing radiation are more effective at generating reactive oxygen spec...
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ژورنال
عنوان ژورنال: Journal of Radiation Research
سال: 2007
ISSN: 0449-3060,1349-9157
DOI: 10.1269/jrr.06090